Diseases / Abdominal Pain
Abdominal Pain
DiseaseAbdominal pain (stomach ache) is a symptom that can be associated with both minor and serious medical conditions. Because many vital organs lie in the abdomen, abdominal pain has a broad differential diagnosis and requires careful evaluation.
- Trials
- 360
- Recruiting
- 26
- Completed
- 228
- With results
- 42
Last revised
Pipeline
Phase by status
| Phase | Recruiting | Not yet | By invitation | Active | Completed | Terminated | Withdrawn | Suspended | Unknown | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| Early Phase 1 | — | — | — | — | 1 | — | — | — | — | 1 |
| Phase 1 | 1 | — | — | — | 4 | 1 | 2 | — | — | 8 |
| Phase 1/2 | 2 | — | — | — | 4 | — | — | — | 1 | 7 |
| Phase 2 | 1 | — | — | — | 22 | 3 | — | 1 | 3 | 30 |
| Phase 2/3 | — | — | — | — | 8 | — | 1 | — | 1 | 10 |
| Phase 3 | 1 | 2 | — | — | 22 | 3 | 1 | — | 3 | 32 |
| Phase 4 | — | — | — | — | 19 | 4 | — | — | 2 | 25 |
| Not applicable | 15 | 13 | — | 2 | 106 | 6 | 5 | — | 22 | 169 |
| Unknown | 6 | 3 | 2 | — | 42 | 7 | 3 | — | 15 | 78 |
Trials started per year
Conditions studied, by phase
| Condition | Early Phase 1 | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | Phase 4 | Not applicable | Unknown | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| Abdominal Pain | 1 | 8 | 7 | 30 | 10 | 32 | 25 | 169 | 78 | 360 |
| Irritable Bowel Syndrome | — | 1 | 2 | 9 | 3 | 5 | 4 | 41 | 12 | 77 |
| Diarrhea | 1 | 1 | 1 | 8 | 1 | 8 | 2 | 24 | 9 | 55 |
| Constipation | 1 | — | 1 | 2 | — | 3 | 1 | 17 | 6 | 31 |
| Nausea | — | — | 1 | 3 | 1 | 4 | 4 | 8 | 7 | 28 |
| Vomiting | — | — | 1 | 3 | — | 4 | 2 | 10 | 5 | 25 |
| Gastrointestinal Diseases | — | 1 | 1 | 3 | — | — | 1 | 13 | 3 | 22 |
| Dyspepsia | — | — | 1 | — | 2 | 2 | 1 | 8 | 4 | 18 |
| Emergencies | — | — | — | — | — | 3 | — | 6 | 7 | 16 |
| Appendicitis | — | — | — | — | — | 5 | — | 1 | 8 | 14 |
Most active sponsors
| # | Sponsor | Trials | Phase 3 |
|---|---|---|---|
| 1 | Baylor College of Medicine | 9 | 0 |
| 2 | Maastricht University Medical Center | 7 | 1 |
| 3 | Karolinska Institutet | 5 | 0 |
| 4 | Mayo Clinic | 5 | 2 |
| 5 | Stanford University | 5 | 0 |
| 6 | Abbott | 4 | 2 |
| 7 | Bausch Health Americas, Inc. | 4 | 2 |
| 8 | Radboud University Medical Center | 4 | 0 |
| 9 | Seattle Children's Hospital | 4 | 0 |
| 10 | Assiut University | 3 | 0 |
Most studied interventions
| # | Intervention | Trials |
|---|---|---|
| 1 | Cognitive Behavioral Therapy | 6 |
| 2 | Morphine | 6 |
| 3 | Acupuncture Therapy | 5 |
| 4 | Probiotics | 5 |
| 5 | Control Groups | 4 |
| 6 | Lidocaine | 4 |
| 7 | Diet Therapy | 3 |
| 8 | Dronabinol | 3 |
| 9 | Ketorolac Tromethamine | 3 |
| 10 | Ondansetron | 3 |
Evidence
- Results reported
- 18.4%42 of 228 completed
- Published
- 13.6%31 of 228 completed
- Primary endpoint met
- 28%14 of 50 analyses
- Median months to report
- 15.5
Documents disclosed
Trial profile
- Median enrollment
- 80
- Median duration
- 19.7months
- Countries
- 53
- Study sites
- 1114
Who is enrolled
Median enrollment by phase
- Early Phase 1
- 20
- Phase 1
- 18
- Phase 1/2
- 39
- Phase 2
- 115
- Phase 2/3
- 81
- Phase 3
- 181
- Phase 4
- 76
- Not applicable
- 66
- Unknown
- 123
Where trials run
Busiest cities
| # | City | Country | Trials |
|---|---|---|---|
| 1 | Houston | United States | 22 |
| 2 | Boston | United States | 14 |
| 3 | Los Angeles | United States | 14 |
| 4 | San Diego | United States | 14 |
| 5 | Cleveland | United States | 10 |
| 6 | Columbus | United States | 10 |
| 7 | Ann Arbor | United States | 9 |
| 8 | Cincinnati | United States | 9 |
| 9 | Kansas City | United States | 9 |
| 10 | Milwaukee | United States | 9 |
Terminations
- Terminated
- 24
- Withdrawn
- 12
- Suspended
- 1
- Stopped for recruitment
- 3.1%11 of 360 trials
Stated reasons
Reasons are grouped from the sponsor's own wording with a rule-based classifier; the original text is shown below.
Recently stopped
| Trial | Status | Stated reason | Stopped |
|---|---|---|---|
| NCT05408910 Withdrawn | Withdrawn | new drug formulation by the manufacturer | 2025-09-30 |
| NCT05696301 Terminated | Terminated | Our low recruitment is related to the fact that few women are in pain in our department 6 to 8 weeks postpartum. It was therefore decided not to extend this study. | 2025-09-19 |
| NCT04057664 Terminated | Terminated | The group therapy program is no longer offered at the site, because other group therapies appear to be better integrated into patients' daily lives. | 2024-12-04 |
| NCT05635214 Withdrawn | Withdrawn | Poor community engagement | 2023-11-01 |
| NCT04497870 Withdrawn | Withdrawn | This study was superseded by NCT03295747 | 2023-09-14 |
| NCT04231279 Terminated | Terminated | Data collection discontinuity and sponsor reallocation of study resources to manufacturing | 2023-06-15 |
| NCT03336034 Terminated | Terminated | Slow inclusion rate. | 2022-05-01 |
| NCT04398316 Terminated | Terminated | Administrative | 2021-06-30 |
| NCT04408872 Withdrawn | Withdrawn | Study was not approved by the institution's scientific committee. | 2021-06-30 |
| NCT04043455 Terminated | Terminated | Business Decision | 2021-04-29 |
Trial records
Individual study records live on ClinicalTrials.gov. A sample of the trials counted above: