Diseases / Acute Kidney Injury
Acute Kidney Injury
DiseaseAcute kidney injury (AKI) is a sudden decrease in kidney function that develops within days and is detected by rising serum creatinine and/or reduced urine output. It is clinically important because it is common in hospitalized and critically ill patients and is associated with major complications.
- Trials
- 1594
- Recruiting
- 181
- Completed
- 801
- With results
- 102
Last revised
Pipeline
Phase by status
| Phase | Recruiting | Not yet | By invitation | Active | Completed | Terminated | Withdrawn | Suspended | Unknown | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| Early Phase 1 | — | 2 | — | 1 | 3 | 1 | — | — | 2 | 9 |
| Phase 1 | 1 | 1 | — | — | 16 | 3 | 4 | — | 2 | 27 |
| Phase 1/2 | 2 | 1 | — | 1 | 5 | — | — | — | 4 | 13 |
| Phase 2 | 21 | 5 | — | 2 | 49 | 14 | 8 | — | 11 | 110 |
| Phase 2/3 | 2 | 4 | — | 2 | 9 | 5 | 2 | — | 6 | 30 |
| Phase 3 | 7 | 1 | — | 2 | 31 | 11 | 3 | 1 | 16 | 72 |
| Phase 4 | 13 | 8 | — | 2 | 42 | 14 | 3 | 2 | 23 | 107 |
| Not applicable | 63 | 36 | 1 | 10 | 221 | 33 | 13 | 1 | 66 | 444 |
| Unknown | 72 | 50 | 10 | 22 | 425 | 18 | 23 | — | 162 | 782 |
Trials started per year
Conditions studied, by phase
| Condition | Early Phase 1 | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | Phase 4 | Not applicable | Unknown | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| Acute Kidney Injury | 9 | 27 | 13 | 110 | 30 | 72 | 107 | 444 | 782 | 1594 |
| Sepsis | — | — | 4 | 6 | 1 | 5 | 8 | 23 | 52 | 99 |
| Renal Insufficiency, Chronic | 2 | 2 | — | 1 | 2 | 5 | 5 | 24 | 51 | 92 |
| Critical Illness | — | — | 2 | 4 | 4 | 4 | 5 | 17 | 51 | 87 |
| Renal Insufficiency | — | 3 | 1 | 3 | 2 | 3 | 2 | 20 | 43 | 77 |
| Shock, Septic | 1 | — | — | 3 | 1 | 4 | 4 | 22 | 19 | 54 |
| Kidney Failure, Chronic | — | 2 | — | 2 | — | 3 | 5 | 10 | 18 | 40 |
| COVID-19 | — | — | 1 | 3 | 1 | 2 | 1 | 5 | 20 | 33 |
| Heart Failure | — | — | — | 2 | 1 | 1 | 1 | 10 | 16 | 31 |
| Kidney Diseases | — | — | — | 1 | 2 | 2 | 3 | 5 | 18 | 31 |
Most active sponsors
| # | Sponsor | Trials | Phase 3 |
|---|---|---|---|
| 1 | Assiut University | 30 | 0 |
| 2 | Assistance Publique - Hôpitaux de Paris | 19 | 5 |
| 3 | Yonsei University | 18 | 0 |
| 4 | Hospices Civils de Lyon | 17 | 0 |
| 5 | Seoul National University Hospital | 17 | 2 |
| 6 | Children's Hospital Medical Center, Cincinnati | 14 | 1 |
| 7 | National Taiwan University Hospital | 14 | 1 |
| 8 | Peking University First Hospital | 14 | 1 |
| 9 | University Hospital, Ghent | 12 | 1 |
| 10 | Ain Shams University | 11 | 0 |
Most studied interventions
| # | Intervention | Trials |
|---|---|---|
| 1 | Saline Solution | 47 |
| 2 | Sodium Chloride | 39 |
| 3 | Continuous Renal Replacement Therapy | 31 |
| 4 | Standard of Care | 27 |
| 5 | Sodium Bicarbonate | 19 |
| 6 | Blood Specimen Collection | 18 |
| 7 | Renal Replacement Therapy | 18 |
| 8 | Cardiac Surgical Procedures | 14 |
| 9 | Acetylcysteine | 13 |
| 10 | Furosemide | 13 |
Evidence
- Results reported
- 12.7%102 of 801 completed
- Published
- 19.2%154 of 801 completed
- Primary endpoint met
- 19.7%12 of 61 analyses
- Median months to report
- 16.5
Documents disclosed
Trial profile
- Median enrollment
- 110
- Median duration
- 24months
- Countries
- 85
- Study sites
- 3380
Who is enrolled
Median enrollment by phase
- Early Phase 1
- 90
- Phase 1
- 16
- Phase 1/2
- 70
- Phase 2
- 90
- Phase 2/3
- 76
- Phase 3
- 122
- Phase 4
- 90
- Not applicable
- 100
- Unknown
- 150
Where trials run
Busiest cities
| # | City | Country | Trials |
|---|---|---|---|
| 1 | Seoul | South Korea | 53 |
| 2 | Beijing | China | 50 |
| 3 | Boston | United States | 47 |
| 4 | Baltimore | United States | 44 |
| 5 | Birmingham | United States | 42 |
| 6 | Cincinnati | United States | 40 |
| 7 | London | United Kingdom | 39 |
| 8 | Dallas | United States | 37 |
| 9 | Houston | United States | 36 |
| 10 | New York | United States | 34 |
Terminations
- Terminated
- 99
- Withdrawn
- 56
- Suspended
- 4
- Stopped for recruitment
- 2.4%39 of 1594 trials
Stated reasons
Reasons are grouped from the sponsor's own wording with a rule-based classifier; the original text is shown below.
Recently stopped
| Trial | Status | Stated reason | Stopped |
|---|---|---|---|
| NCT04598516 Withdrawn | Withdrawn | delay | 2099-11-01 |
| NCT04603261 Withdrawn | Withdrawn | delayed | 2099-11-01 |
| NCT04597892 Withdrawn | Withdrawn | delay | 2099-03-01 |
| NCT05114057 Withdrawn | Withdrawn | Inadequate funding | 2029-07-01 |
| NCT07198906 Withdrawn | Withdrawn | no Inclusion | 2029-04-01 |
| NCT04898010 Suspended | Suspended | On hold while seeking funding. | 2027-10-31 |
| NCT07108634 Withdrawn | Withdrawn | Funded by company allocated elsewhere. | 2027-03-31 |
| NCT03974347 Withdrawn | Withdrawn | Logistical problmens, collisions with other studies | 2026-09-01 |
| NCT05921695 Terminated | Terminated | Terminated due to protocol amendment: intervention window changed from entire ED stay to first 2h after ED admission. Revised protocol will be registered separately. | 2026-06-01 |
| NCT06374797 Terminated | Terminated | The study was stopped due to imbalance in randomization stratification of severe patients. | 2026-04-06 |
Trial records
Individual study records live on ClinicalTrials.gov. A sample of the trials counted above:
Search all Acute Kidney Injury trials on ClinicalTrials.gov →