Diseases / Autism Spectrum Disorder
Autism Spectrum Disorder
DiseaseAutism spectrum disorder (ASD) is a neurodevelopmental condition characterized by persistent differences in social communication and interaction, alongside restricted or repetitive patterns of behavior, interests, or activities.
- Trials
- 1690
- Recruiting
- 285
- Completed
- 882
- With results
- 189
Last revised
Pipeline
Phase by status
| Phase | Recruiting | Not yet | By invitation | Active | Completed | Terminated | Withdrawn | Suspended | Unknown | No longer available | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Early Phase 1 | 2 | 2 | — | — | 9 | — | — | — | 2 | — | 15 |
| Phase 1 | 2 | 3 | — | 1 | 30 | 2 | 3 | 1 | 4 | — | 46 |
| Phase 1/2 | 3 | 2 | 1 | — | 11 | 1 | — | — | 1 | — | 19 |
| Phase 2 | 22 | 6 | 1 | 10 | 77 | 13 | 10 | 1 | 8 | — | 148 |
| Phase 2/3 | 2 | — | 1 | — | 5 | 1 | 1 | — | 2 | — | 12 |
| Phase 3 | 2 | 3 | — | — | 22 | 6 | 1 | — | 1 | — | 35 |
| Phase 4 | 3 | 1 | — | — | 16 | 2 | — | — | 1 | — | 23 |
| Not applicable | 189 | 67 | 17 | 44 | 567 | 29 | 16 | — | 143 | — | 1072 |
| Unknown | 60 | 17 | 6 | 13 | 145 | 6 | 4 | 2 | 66 | 1 | 320 |
Trials started per year
Conditions studied, by phase
| Condition | Early Phase 1 | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | Phase 4 | Not applicable | Unknown | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| Autism Spectrum Disorder | 15 | 46 | 19 | 148 | 12 | 35 | 23 | 1072 | 320 | 1690 |
| Autistic Disorder | 4 | 15 | 9 | 59 | 4 | 16 | 9 | 285 | 87 | 488 |
| Attention Deficit Disorder with Hyperactivity | 1 | — | 1 | 3 | — | 1 | 4 | 50 | 25 | 85 |
| Anxiety Disorders | 2 | — | — | 9 | — | — | 2 | 48 | 6 | 67 |
| Neurodevelopmental Disorders | — | 1 | — | 3 | — | — | — | 40 | 20 | 64 |
| Child Development Disorders, Pervasive | — | 1 | 1 | 8 | — | 3 | 1 | 29 | 15 | 58 |
| Intellectual Disability | — | 1 | — | 1 | — | — | — | 33 | 23 | 58 |
| Asperger Syndrome | — | 1 | 1 | 9 | — | 2 | 2 | 22 | 13 | 50 |
| Communication | — | 1 | 1 | 3 | — | — | — | 38 | 1 | 44 |
| Developmental Disabilities | — | — | 1 | 3 | — | — | — | 25 | 13 | 42 |
Most active sponsors
| # | Sponsor | Trials | Phase 3 |
|---|---|---|---|
| 1 | National Taiwan University Hospital | 42 | 0 |
| 2 | Stanford University | 40 | 4 |
| 3 | Massachusetts General Hospital | 37 | 5 |
| 4 | Riphah International University | 28 | 0 |
| 5 | Yale University | 24 | 0 |
| 6 | Holland Bloorview Kids Rehabilitation Hospital | 22 | 1 |
| 7 | Istituto per la Ricerca e l'Innovazione Biomedica | 22 | 0 |
| 8 | Children's Hospital Medical Center, Cincinnati | 21 | 0 |
| 9 | Chinese University of Hong Kong | 18 | 0 |
| 10 | Emory University | 18 | 1 |
Most studied interventions
| # | Intervention | Trials |
|---|---|---|
| 1 | Therapeutics | 34 |
| 2 | Oxytocin | 18 |
| 3 | Transcranial Magnetic Stimulation | 18 |
| 4 | Cognitive Behavioral Therapy | 17 |
| 5 | Behavior Therapy | 13 |
| 6 | Exercise | 12 |
| 7 | Transcranial Direct Current Stimulation | 12 |
| 8 | Control Groups | 11 |
| 9 | Fecal Microbiota Transplantation | 9 |
| 10 | Leucovorin | 9 |
Evidence
- Results reported
- 21.4%189 of 882 completed
- Published
- 9.6%85 of 882 completed
- Primary endpoint met
- 36.1%78 of 216 analyses
- Median months to report
- 14
Documents disclosed
Trial profile
- Median enrollment
- 59
- Median duration
- 26.1months
- Countries
- 66
- Study sites
- 2288
Who is enrolled
Median enrollment by phase
- Early Phase 1
- 22
- Phase 1
- 25
- Phase 1/2
- 20
- Phase 2
- 50
- Phase 2/3
- 90
- Phase 3
- 98
- Phase 4
- 40
- Not applicable
- 52
- Unknown
- 100
Where trials run
Busiest cities
| # | City | Country | Trials |
|---|---|---|---|
| 1 | Boston | United States | 66 |
| 2 | Nashville | United States | 48 |
| 3 | Phoenix | United States | 45 |
| 4 | New York | United States | 44 |
| 5 | Toronto | Canada | 43 |
| 6 | Cincinnati | United States | 41 |
| 7 | Philadelphia | United States | 40 |
| 8 | Stanford | United States | 40 |
| 9 | Los Angeles | United States | 39 |
| 10 | Seattle | United States | 39 |
Terminations
- Terminated
- 60
- Withdrawn
- 35
- Suspended
- 4
- Stopped for recruitment
- 0.8%14 of 1690 trials
Stated reasons
Reasons are grouped from the sponsor's own wording with a rule-based classifier; the original text is shown below.
Recently stopped
| Trial | Status | Stated reason | Stopped |
|---|---|---|---|
| NCT04031469 Suspended | Suspended | Administrative | 2030-12-10 |
| NCT04100863 Withdrawn | Withdrawn | Company focus shifted | 2030-06-30 |
| NCT06259201 Withdrawn | Withdrawn | Investigator decided to terminate the study - no participant enrolled. | 2027-12-31 |
| NCT07047976 Withdrawn | Withdrawn | Study terminated prior to full implementation due to logistical and resource-related considerations. Study procedures and feasibility are currently being re-evaluated, and a revised protocol is under development for future implementation. | 2026-07-01 |
| NCT06794476 Withdrawn | Withdrawn | Investigator left Vanderbilt University Medical Center and trial had not yet enrolled any participants. | 2026-03-18 |
| NCT04909710 Withdrawn | Withdrawn | we are suspending this study until we have continued funding. | 2026-02-28 |
| NCT05456139 Terminated | Terminated | NIMH determined that the grant was not feasible due to lack of sufficient participant recruitment and negotiated a bilateral termination of this grant on 04/01/2025. Recruitment was halted and an orderly phase-out plan was approved and implemented. | 2026-01-31 |
| NCT03553875 Terminated | Terminated | requested by the IRB | 2025-11-25 |
| NCT05098392 Terminated | Terminated | Difficulty in recruiting required participants. | 2025-09-07 |
| NCT03432065 Withdrawn | Withdrawn | This study was withdrawn due to competing research interests and slow recruitment. | 2025-08-31 |
Trial records
Individual study records live on ClinicalTrials.gov. A sample of the trials counted above:
Search all Autism Spectrum Disorder trials on ClinicalTrials.gov →