Diseases / Myocardial Infarction
Myocardial Infarction
DiseaseMyocardial infarction (heart attack) occurs when coronary blood flow is severely reduced or blocked, causing ischemic injury and necrosis of heart muscle. It is a major cause of cardiovascular morbidity and mortality.
- Trials
- 1951
- Recruiting
- 178
- Completed
- 1096
- With results
- 183
Last revised
Pipeline
Phase by status
| Phase | Recruiting | Not yet | By invitation | Active | Completed | Terminated | Withdrawn | Suspended | Unknown | Available | Temporarily not available | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Early Phase 1 | 1 | 1 | — | — | 3 | — | — | — | 1 | — | — | 6 |
| Phase 1 | 1 | 1 | — | — | 24 | 3 | 2 | — | 5 | — | — | 36 |
| Phase 1/2 | — | — | — | — | 18 | 4 | 3 | — | 10 | — | — | 35 |
| Phase 2 | 6 | 3 | 1 | 3 | 62 | 12 | 5 | — | 17 | — | — | 109 |
| Phase 2/3 | 2 | 1 | — | — | 18 | 5 | — | — | 6 | — | — | 32 |
| Phase 3 | 12 | 1 | — | 1 | 131 | 15 | 4 | 1 | 19 | — | — | 184 |
| Phase 4 | 17 | 5 | — | 4 | 124 | 15 | 5 | — | 44 | — | — | 214 |
| Not applicable | 61 | 24 | 7 | 28 | 297 | 28 | 14 | 2 | 111 | — | — | 572 |
| Unknown | 78 | 28 | 6 | 33 | 419 | 20 | 16 | — | 161 | 1 | 1 | 763 |
Trials started per year
Conditions studied, by phase
| Condition | Early Phase 1 | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | Phase 4 | Not applicable | Unknown | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| Myocardial Infarction | 6 | 36 | 35 | 109 | 32 | 184 | 214 | 572 | 763 | 1951 |
| Coronary Artery Disease | 2 | 8 | 3 | 16 | 3 | 18 | 26 | 116 | 108 | 300 |
| Cardiovascular Diseases | 1 | 5 | 2 | 11 | 1 | 54 | 21 | 54 | 136 | 285 |
| Acute Coronary Syndrome | 1 | 2 | 2 | 12 | 1 | 29 | 22 | 56 | 111 | 236 |
| Stroke | 1 | 3 | 1 | 2 | 4 | 29 | 25 | 42 | 123 | 230 |
| Myocardial Ischemia | 1 | 3 | 3 | 17 | 3 | 35 | 12 | 44 | 68 | 186 |
| Heart Failure | 1 | 8 | 4 | 11 | 3 | 19 | 7 | 45 | 83 | 181 |
| Heart Diseases | — | 4 | 3 | 10 | 2 | 38 | 8 | 21 | 91 | 177 |
| ST Elevation Myocardial Infarction | — | 3 | 3 | 15 | 3 | 20 | 22 | 58 | 52 | 176 |
| Coronary Disease | — | 2 | 1 | 9 | — | 28 | 8 | 26 | 87 | 161 |
Most active sponsors
| # | Sponsor | Trials | Phase 3 |
|---|---|---|---|
| 1 | National Heart, Lung, and Blood Institute (NHLBI) | 64 | 20 |
| 2 | University of Edinburgh | 19 | 0 |
| 3 | Mayo Clinic | 18 | 1 |
| 4 | Brigham and Women's Hospital | 17 | 3 |
| 5 | AstraZeneca | 16 | 3 |
| 6 | Karolinska Institutet | 16 | 2 |
| 7 | University College, London | 16 | 0 |
| 8 | Assistance Publique - Hôpitaux de Paris | 14 | 6 |
| 9 | Assiut University | 13 | 0 |
| 10 | Deutsches Herzzentrum Muenchen | 13 | 1 |
Most studied interventions
| # | Intervention | Trials |
|---|---|---|
| 1 | Clopidogrel | 53 |
| 2 | Aspirin | 44 |
| 3 | Ticagrelor | 43 |
| 4 | Percutaneous Coronary Intervention | 37 |
| 5 | Standard of Care | 20 |
| 6 | Atorvastatin | 19 |
| 7 | Abciximab | 16 |
| 8 | Prasugrel Hydrochloride | 16 |
| 9 | Blood Specimen Collection | 15 |
| 10 | Exercise | 12 |
Evidence
- Results reported
- 16.7%183 of 1096 completed
- Published
- 21.6%237 of 1096 completed
- Primary endpoint met
- 41.1%60 of 146 analyses
- Median months to report
- 17.5
Documents disclosed
Trial profile
- Median enrollment
- 220
- Median duration
- 37.1months
- Countries
- 95
- Study sites
- 16820
Who is enrolled
Median enrollment by phase
- Early Phase 1
- 105
- Phase 1
- 25
- Phase 1/2
- 27
- Phase 2
- 98
- Phase 2/3
- 106
- Phase 3
- 568
- Phase 4
- 240
- Not applicable
- 131
- Unknown
- 543
Where trials run
Busiest cities
| # | City | Country | Trials |
|---|---|---|---|
| 1 | New York | United States | 76 |
| 2 | Boston | United States | 67 |
| 3 | London | United Kingdom | 67 |
| 4 | Barcelona | Spain | 63 |
| 5 | Paris | France | 60 |
| 6 | Toronto | Canada | 60 |
| 7 | Houston | United States | 59 |
| 8 | Rochester | United States | 59 |
| 9 | Seoul | South Korea | 58 |
| 10 | Montreal | Canada | 57 |
Terminations
- Terminated
- 102
- Withdrawn
- 49
- Suspended
- 3
- Stopped for recruitment
- 1.2%23 of 1951 trials
Stated reasons
Reasons are grouped from the sponsor's own wording with a rule-based classifier; the original text is shown below.
Recently stopped
| Trial | Status | Stated reason | Stopped |
|---|---|---|---|
| NCT02503280 Withdrawn | Withdrawn | Study has never enrolled any subjects | 2032-03-31 |
| NCT06742684 Withdrawn | Withdrawn | The study could not be started due to a lack of funding for the provision of the medical product to be investigated. | 2029-08-31 |
| NCT05494151 Withdrawn | Withdrawn | Due to unforeseen challenges in participant recruitment and retention, the study was early terminated to maintain the integrity of the data and ensure ethical standards were upheld. | 2026-09-01 |
| NCT04218786 Withdrawn | Withdrawn | Due to the pandemic, there were logistical issues in continuing the study. | 2026-06-30 |
| NCT05720156 Withdrawn | Withdrawn | Lack of Feasibility | 2026-03-31 |
| NCT03729401 Terminated | Terminated | Testing supplies unavailable. | 2026-02-26 |
| NCT07693712 Terminated | Terminated | Staffing challenges and subsequent withdrawal of funding. | 2026-02-26 |
| NCT06139328 Terminated | Terminated | Sponsor decision | 2025-12-02 |
| NCT03289728 Terminated | Terminated | According interim analysis results | 2025-07-28 |
| NCT06280976 Withdrawn | Withdrawn | study withdrawn, no participants enrolled, changes in the study design planned | 2025-01-01 |
Trial records
Individual study records live on ClinicalTrials.gov. A sample of the trials counted above:
Search all Myocardial Infarction trials on ClinicalTrials.gov →